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首页> 外文OA文献 >In Vitro Antifungal Activity of Micafungin (FK463) against Dimorphic Fungi: Comparison of Yeast-Like and Mycelial Forms
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In Vitro Antifungal Activity of Micafungin (FK463) against Dimorphic Fungi: Comparison of Yeast-Like and Mycelial Forms

机译：米卡芬净（FK463）对双态真菌的体外抗真菌活性：酵母样和菌丝体形式的比较

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The characteristics of in vitro micafungin (FK463) antifungal activity against six species of dimorphic fungi were investigated in accordance with the NCCLS M27-A microdilution methods. MICs of micafungin, amphotericin B, itraconazole, and fluconazole for Histoplasma capsulatum var. capsulatum, Blastomyces dermatitidis, Paracoccidioides brasiliensis, Penicillium marneffei, and Sporothrix schenckii were determined both for the yeast-like form and mycelial form. Coccidioides immitis was tested only in its mycelial form. We have clearly demonstrated that the in vitro activity of micafungin depends considerably on the growth form of dimorphic fungi. Micafungin exhibited potent activity against the mycelial forms of H. capsulatum, B. dermatitidis, and C. immitis (MIC range, 0.0078 to 0.0625 μg/ml), while it was very weakly active against their yeast-like forms (MIC range, 32 to >64 μg/ml). Micafungin was also more active against the mycelial forms than the yeast-like forms of Paracoccidioides brasiliensis, Penicillium marneffei, and S. schenckii. The MICs of amphotericin B were 2 to 5 dilutions lower for the mycelial forms than for the yeast-like forms of B. dermatitidis and Paracoccidioides brasiliensis. There was no apparent difference in the activity of itraconazole between the two forms. The MICs of fluconazole for the yeast-like forms were generally lower than those for the mycelial forms, and considerably so for B. dermatitidis. These results suggest that the growth form employed in antifungal susceptibility testing of dimorphic fungi can considerably influence the interpretation of results. At present, it cannot be judged whether micafungin has clinical usefulness for dimorphic fungus infections, since for most fungi it remains uncertain which growth form correlates better with therapeutic outcome. However, the results of this study warrant further investigations of micafungin as a therapeutic agent for infections caused by dimorphic fungi.
机译：根据NCCLS M27-A微量稀释法研究了米卡芬净（FK463）对6种双态真菌的体外抗真菌活性。米卡芬净，两性霉素B，伊曲康唑和氟康唑的荚膜组织胞浆的MIC。对于酵母样形式和菌丝体形式，均测定了荚膜，皮肤芽孢杆菌，巴西副球菌，马尔尼菲青霉和申氏孢子菌。仅以菌丝体形式测试了球虫球菌性炎。我们已经清楚地证明了米卡芬净的体外活性在很大程度上取决于双态真菌的生长形式。米卡芬净对荚膜梭菌，皮肤病双歧杆菌和C. immitis的菌丝体形式表现出有效的活性（MIC范围为0.0078至0.0625μg/ ml），而对它们的酵母样形式的活性很弱（MIC范围为32）至> 64μg/ ml）。与霉菌类巴西对虾，马尔尼菲青霉菌和申氏链球菌的酵母样形式相比，米卡芬净对菌丝体的活性也更高。两性霉素B的MIC比菌丝形式的B. dermatitidis和Brasiliccidiaides Brasiliensis的酵母样形式低2至5倍。两种形式的伊曲康唑活性没有明显差异。酵母样形式的氟康唑的MIC普遍低于菌丝体形式的MIC，而皮肤病双歧杆菌的MIC则要低得多。这些结果表明，用于双态真菌抗真菌药敏试验的生长形式会大大影响结果的解释。目前，尚不能判断米卡芬净是否对二形性真菌感染具有临床价值，因为对于大多数真菌而言，仍不确定哪种生长形式与治疗效果更好相关。但是，这项研究的结果值得进一步研究米卡芬净作为治疗双态性真菌引起的感染的治疗剂。

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